Hanns Lochmüller
PROFESSOR OF NEUROLOGY
Dr. Hanns Lochmüller - ProDGNE Biosketch
Dr. Hanns Lochmüller is a Senior Scientist at the Children’s Hospital of Eastern Ontario Research Institute and holds appointments as Professor of Neurology at the University of Ottawa Brain and Mind Research Institute and at The Ottawa Hospital. He also continues to hold scientific appointments at the Department of Neuropediatrics and Muscle Disorders at the University of Freiburg in Germany and at the Centro Nacional de Análisis Genómico, Centre for Genomic Regulation, in Barcelona, Spain.
Dr. Hanns Lochmüller’s translational research lab works toward developing therapies for muscle and neuromuscular disorders and identifying the molecular mechanisms behind these disorders. The Lochmüller Lab has extensive experience in generating and characterising animal models for these disorders, including zebrafish, and performing drug screens to test novel therapeutic strategies. Hanns Lochmüller also recently led the first phase 3 clinical trial for GNE myopathy.
Role in ProDGNE
The role of the Lochmüller lab within ProDGNE is to lead work package five. The Lochmüller Lab’s main objective is to determine the safest and most promising lead compounds that come out of the in vitro testing performed in work package two; this will involve using appropriate GNEM animal models, such as an established GNEM zebrafish, and screening for potential toxicity and improvements in disease phenotype. The Lochmüller Lab will also contribute proteomics experiments for the identification of biomarkers to assess the longitudinal effects of different compounds as part of work package four.
