Fabrizio Pertusati
LECTURER IN MEDICINAL CHEMISTRY
Dr Fabrizio Pertusati Is a lecturer in Medicinal chemistry at Cardiff University. Dr. Pertusati holds a M.Sc. in physical organic chemistry (synthesis and characterisation of fluorinated Gemini surfactants) and a PhD in asymmetric organic synthesis (atropisomeric biquinazolinones) from Cardiff university.
He received postdoctoral training in solid-phase organic synthesis at Emory University and in organofluorine and organoboron chemistry in the group of Nobel laureate Professor George Olah.
From 2011 until 2016 he has been trained as a medicinal chemist in the laboratory of Prof. Chris McGuigan on various drug discovery projects (phosphoramidate prodrugs as antiviral and anticancer agents, fluorinated androgen-receptors antagonist for prostate cancer treatment, and design/synthesis of compounds acting on the Central Nervous System.
In 2017 he was promoted to research fellow and in 2018 received a two years-fixed term lectureship sponsored by Nucana Plc. From January 2020 he became a permanent lecturer in medicinal chemistry at the Cardiff School of Pharmacy and Pharmaceutical Sciences.
Dr. Pertusati laboratory has extensive expertise in the synthesis of a wide variety of small molecules with focus on phosphate prodrugs and fluorinated molecules. Current research interests are in the drug discovery of small molecules for the treatment of rare diseases. Main research topics are congenital disorder of glycosylation (GNE myopathy, PMM2), cystinosis, Nieman-Pick and recently ADSSL1.
To date, Dr. Pertusati has authored and co-authored more that 46 peer-reviewed papers, 2 books chapters, and he is a named inventor in 8 patents (issued and pending) in the area of small molecules therapeutics. He has served as a member of the Scientific Advisor Board of Ichorion Therapeutics.
Role in ProDGNE
In ProDGNE Fabrizio Pertusati leads the work on the design and synthesis of the prodrugs.
